Abstract

Two possibilities should be considered for the origin of SARS-CoV-2 natural evolution or laboratory creation In our earlier paper titled Unusual Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory Modification as a Biological Robot Rather than Natural Evolution and Delineation of its Probable Synthetic Route we disproved the possibility of SARSCoV- 2 arising naturally through evolution and instead proved that SARS-CoV-2 must have been a product of laboratory modification Despite this and similar efforts the laboratory creation theory continues to be downplayed or even diminished This is fundamentally because the natural origin theory remains supported by several novel coronaviruses published after the start of the outbreak These viruses the RaTG13 bat coronavirus a series of pangolin coronaviruses and the RmYN02 bat coronavirus reportedly share high sequence homology with SARS-CoV-2 and have altogether constructed a seemingly plausible pathway for the natural evolution of SARSCoV- 2 Here however we use in-depth analyses of the available data and literature to prove that these novel animal coronaviruses do not exist in nature and their sequences have been fabricated In addition we also offer our insights on the hypothesis that SARS-CoV-2 may have originated naturally from a coronavirus that infected the Mojiang miners