The Global Hospital Information Systems market is forecast to grow at a Compound Annual Growth Rate of 10% from 2010-2017. Healthcare organizations globally recognize the importance of investing in information technologies. The HIS systems are large computerized data bases intended primarily for communication, store health and administrative information. It is evident that the use of HIS offers tremendous opportunities to reduce clinical errors, support health care professionals decision making, increases the efficiency and quality of patient care. The development, testing, and adoption of HIS remain limited and numerous barriers exist. There is an urgent need to take a fresh look at HIS. The advancement of information system and technologies made various new applications possible. The purpose of this study is to understand infrastructure, system practices, hindering and motivating forces behind HIS at a tertiary teaching hospital which is explorative in nature. The study also focuses on details about hardware, operational procedure and other important facts pertaining to forces resulting in acceptance of HIS.