This paper proposes a framework of domain Ontology - based scientific and information retrieval (IR), and makes in - depth study on information organization and semantic
retrieval. A prototype information retrieval information system is also implemented via a series of retrieval effects tests. The domain Ontology - based retrieval information system and the retrieval process of the information systematic prototypes are also depicted. In the end, the model is validated through a platform of trial information system. The result shows that when
contrasted with traditional retrieval information system; this information system has a strong function in extending the connotation and denotation of the search words. So, it has the superiority in enhancing greatly the precision and recall.